NET1

Neuroepitelni ćelijsko transformišući gen 1 protein

Dostupne strukture

3EO2

Identifikatori

NET1; ARHGEF8; NET1A

Vanjski ID

OMIM: 606450 MGI: 1927138 HomoloGene: 4283 GeneCards: NET1 Gene

Ontologija gena
Molekularna funkcija	• aktivnost faktora razmene guanil-nukleotida • fosfolipidno vezivanje
Celularna komponenta	• jedro • citozol
Biološki proces	• regulacija ćelijskog rasta • apoptotički proces • prenos signala

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

10276

56349

Ensembl

ENSG00000173848

ENSMUSG00000021215

UniProt

Q7Z628

Q9Z206

RefSeq (mRNA)

NM_001047160

NM_001047159

RefSeq (protein)

NP_001040625

NP_001040624

Lokacija (UCSC)

Chr 10:
5.45 - 5.5 Mb

Chr 13:
3.88 - 3.92 Mb

PubMed pretraga

[1]

[2]

Neuroepitelni ćelijsko transformišući gen 1 protein je kod čoveka kodiran NET1 genom.^[1]^[2]

Reference

^ Chan AM, Takai S, Yamada K, Miki T (1996). „Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning”. Oncogene. 12 (6): 1259—66. PMID 8649828.
^ „Entrez Gene: NET1 neuroepithelial cell transforming gene 1”.

Literatura

Shen X; Li J; Hu PP; et al. (2001). „The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation.”. J. Biol. Chem. 276 (18): 15362—8. PMID 11278519. doi:10.1074/jbc.M009534200. CS1 одржавање: Експлицитна употреба et al. (веза)
Dobrosotskaya IY (2001). „Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1.”. Biochem. Biophys. Res. Commun. 283 (4): 969—75. PMID 11350080. doi:10.1006/bbrc.2001.4880.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. CS1 одржавање: Експлицитна употреба et al. (веза)
Suzuki Y; Yamashita R; Shirota M; et al. (2004). „Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”. Genome Res. 14 (9): 1711—8. PMC 515316 . PMID 15342556. doi:10.1101/gr.2435604. CS1 одржавање: Експлицитна употреба et al. (веза)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. CS1 одржавање: Експлицитна употреба et al. (веза)
Qin H; Carr HS; Wu X; et al. (2005). „Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1.”. J. Biol. Chem. 280 (9): 7603—13. PMID 15611121. doi:10.1074/jbc.M412141200. CS1 одржавање: Експлицитна употреба et al. (веза)
Alberts AS, Qin H, Carr HS, Frost JA (2005). „PAK1 negatively regulates the activity of the Rho exchange factor NET1.”. J. Biol. Chem. 280 (13): 12152—61. PMID 15684429. doi:10.1074/jbc.M405073200.
Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55—65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406. CS1 одржавање: Експлицитна употреба et al. (веза)
Leyden J; Murray D; Moss A; et al. (2006). „Net1 and Myeov: computationally identified mediators of gastric cancer.”. Br. J. Cancer. 94 (8): 1204—12. PMC 2361249 . PMID 16552434. doi:10.1038/sj.bjc.6603054. CS1 одржавање: Експлицитна употреба et al. (веза)
García-Mata R; Dubash AD; Sharek L; et al. (2007). „The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.”. Mol. Cell. Biol. 27 (24): 8683—97. PMC 2169424 . PMID 17938206. doi:10.1128/MCB.00157-07. CS1 одржавање: Експлицитна употреба et al. (веза)