FSH-receptor

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Struktura interakcije FSH i FSH-receptora

PDB prikaz baziran na 1xwd.
Dostupne strukture
1xwd
Identifikatori
SimboliFSHR; FSHRO; LGR1; MGC141667; MGC141668; ODG1
Vanjski IDOMIM: 136435 MGI: 95583 HomoloGene: 117 IUPHAR: FSH GeneCards: FSHR Gene
Ontologija gena
Molekularna funkcija • aktivnost receptora
• aktivnost folikulostimulišućeg hormonskog receptora
• proteinsko vezivanje
Celularna komponenta • ćelijska membrana
• integralno sa membranom
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• spermatogeneza
• generisanje ženskog gameta
• razvoj ženskog gonada
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez249214309
EnsemblENSG00000170820ENSMUSG00000032937
UniProtP23945P35378
RefSeq (mRNA)NM_000145NM_013523
RefSeq (protein)NP_000136NP_038551
Lokacija (UCSC)Chr 2:
49.04 - 49.24 Mb		Chr 17:
88.89 - 89.11 Mb
PubMed pretraga[1][2]

Folikulostimulišući hormonski receptor ili FSH-receptor (FSHR) je transmembranski receptor koji interaguje sa Folikulostimulišućim hormonom (FSH). On je G protein-spregnuti receptor (GPCR). Njegova aktivacija je neophodna za FSH hormonsko funkcionisanje. FSHR receptori su nađeni u jajnicima, testisima, i uterusu.

FSHR gen

FSHR gen se nalazi na hromozomu 2 p21 kod čoveka. FSHR genska sekvenca se sastoji od oko 2,080 nukleotida.[1]

Struktura receptora

Struktura G protein-spregnutog receptora kao što je FSHR sa sedam transmembranskih α-heliksa

FSHR se sastoji od 695 aminokiselina, i ima molekulsku masu od oko 76 kDa.[1] Poput drugih GPCR receptora, FSH-receptor poseduje sedam domena (transmembranskih heliksa), svaki od kojih premoštava membranu.

  • Transmembranski domen sadrži dva visoko očuvana cisteinska ostatka koji formiraju disulfidnu vezs čime se stabilizuje struktura receptora. Visoko konzervirani Asp-Arg-Tyr triplet je prisutan i verovatno učestvuje u prenosu signala.

Reference

  1. ↑ 1,0 1,1 Simoni M, Gromoll J, Nieschlag E (December 1997). „The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology”. Endocr. Rev. 18 (6): 739–73. DOI:10.1210/er.18.6.739. PMID 9408742. 

Literatura

  • de la Chapelle A (1993). „Disease gene mapping in isolated human populations: the example of Finland.”. J. Med. Genet. 30 (10): 857–65. DOI:10.1136/jmg.30.10.857. PMC 1016570. PMID 8230163. 
  • Amsterdam A, Hanoch T, Dantes A, et al. (2003). „Mechanisms of gonadotropin desensitization.”. Mol. Cell. Endocrinol. 187 (1-2): 69–74. DOI:10.1016/S0303-7207(01)00701-8. PMID 11988313. 
  • Simoni M, Nieschlag E, Gromoll J (2003). „Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction.”. Hum. Reprod. Update 8 (5): 413–21. DOI:10.1093/humupd/8.5.413. PMID 12398222. 
  • Delbaere A, Smits G, Olatunbosun O, et al. (2004). „New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?”. Hum. Reprod. 19 (3): 486–9. DOI:10.1093/humrep/deh124. PMC 2891954. PMID 14998941. 
  • Bose CK (2005). „Role of nerve growth factor and FSH receptor in epithelial ovarian cancer.”. Reprod. Biomed. Online 11 (2): 194–7. DOI:10.1016/S1472-6483(10)60958-3. PMID 16168216. 
  • Wunsch A, Sonntag B, Simoni M (2007). „Polymorphism of the FSH receptor and ovarian response to FSH.”. Ann. Endocrinol. (Paris) 68 (2-3): 160–6. DOI:10.1016/j.ando.2007.04.006. PMID 17544358. 
  • Kelton CA, Cheng SV, Nugent NP, et al. (1993). „The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells.”. Mol. Cell. Endocrinol. 89 (1-2): 141–51. DOI:10.1016/0303-7207(92)90220-Z. PMID 1301382. 
  • Tilly JL, Aihara T, Nishimori K, et al. (1992). „Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts.”. Endocrinology 131 (2): 799–806. DOI:10.1210/en.131.2.799. PMID 1322283. 
  • Gromoll J, Gudermann T, Nieschlag E (1992). „Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor.”. Biochem. Biophys. Res. Commun. 188 (3): 1077–83. DOI:10.1016/0006-291X(92)91341-M. PMID 1359889. 
  • Minegishi T, Nakamura K, Takakura Y, et al. (1991). „Cloning and sequencing of human FSH receptor cDNA.”. Biochem. Biophys. Res. Commun. 175 (3): 1125–30. DOI:10.1016/0006-291X(91)91682-3. PMID 1709010. 
  • Gromoll J, Ried T, Holtgreve-Grez H, et al. (1994). „Localization of the human FSH receptor to chromosome 2 p21 using a genomic probe comprising exon 10.”. J. Mol. Endocrinol. 12 (3): 265–71. DOI:10.1677/jme.0.0120265. PMID 7916967. 
  • Gromoll J, Dankbar B, Gudermann T (1994). „Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene.”. Mol. Cell. Endocrinol. 102 (1-2): 93–102. DOI:10.1016/0303-7207(94)90102-3. PMID 7926278. 
  • Rousseau-Merck MF, Atger M, Loosfelt H, et al. (1993). „The chromosomal localization of the human follicle-stimulating hormone receptor gene (FSHR) on 2p21-p16 is similar to that of the luteinizing hormone receptor gene.”. Genomics 15 (1): 222–4. DOI:10.1006/geno.1993.1041. PMID 8432542. 
  • Jiang X, Dreano M, Buckler DR, et al. (1996). „Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.”. Structure 3 (12): 1341–53. DOI:10.1016/S0969-2126(01)00272-6. PMID 8747461. 
  • Aittomäki K, Herva R, Stenman UH, et al. (1996). „Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene.”. J. Clin. Endocrinol. Metab. 81 (10): 3722–6. DOI:10.1210/jc.81.10.3722. PMID 8855829. 
  • Tapanainen JS, Aittomäki K, Min J, et al. (1997). „Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility.”. Nat. Genet. 15 (2): 205–6. DOI:10.1038/ng0297-205. PMID 9020851. 
  • Kotlar TJ, Young RH, Albanese C, et al. (1997). „A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.”. J. Clin. Endocrinol. Metab. 82 (4): 1020–6. DOI:10.1210/jc.82.4.1020. PMID 9100567. 

Vidi još

Spoljašnje veze

  • „Glycoprotein Hormone Receptors: FSH”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-04-07. 
  • GRIS: Glycoprotein-hormone Receptor Information System Arhivirano 2006-10-16 na Wayback Machine-u
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptidni receptori
Hormonski receptori
CRH - FSH - LHRH - TRH - Somatostatin
Drugi
Opioidni receptori
Drugi neuropeptidni receptori
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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PDB Galerija
Šablon:PDB Galerija/2492