ITPR2

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Inositol 1,4,5-trisphosphate receptor, type 2

Identificadores

ITPR2; CFAP48; IP3R2

IDs externos

OMIM: 600144 MGI: 99418 HomoloGene: 37593 IUPHAR: IP₃R2 ChEMBL: 2512 GeneCards: ITPR2 Gene

Ontologia do gene
Função molecular	•inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity •calcium ion transmembrane transporter activity •phosphatidylinositol binding
Componente celular	•endoplasmic reticulum membrane •plasma membrane •cell cortex •membrane •integral component of membrane •platelet dense tubular network membrane •sarcoplasmic reticulum membrane •receptor complex
Processo biológico	•response to hypoxia •energy reserve metabolic process •transport •signal transduction •epidermal growth factor receptor signaling pathway •activation of phospholipase C activity •blood coagulation •fibroblast growth factor receptor signaling pathway •platelet activation •Fc-epsilon receptor signaling pathway •Fc-gamma receptor signaling pathway involved in phagocytosis •small molecule metabolic process •innate immune response •neurotrophin TRK receptor signaling pathway •inositol phosphate-mediated signaling •regulation of insulin secretion •calcium ion transmembrane transport •cellular response to cAMP •cellular response to ethanol
Sources: Amigo / QuickGO

Ortólogos

Espécies

Humano

Rato

Entrez

3709

16439

Ensembl

ENSG00000123104

ENSMUSG00000030287

UniProt

Q14571

Q9Z329

RefSeq (mRNA)

NM_002223

NM_010586

RefSeq (proteína)

NP_002214

NP_034716

Localização (UCSC)

Chr 12:
26.49 – 26.99 Mb

Chr 6:
146.11 – 146.5 Mb

Busca PubMed

[1]

[2]

ITPR2 (do inglês, inositol 1,4,5-triphosphate receptor, type 2) é uma proteína que é codificado pelo gene humano ITPR2.^[1] A proteína codificada por este gene é um receptor para o inositol trifosfato e um canal de cálcio.^[2]

Ver também

Receptor de inositol trifosfato

Referências

↑ «Entrez Gene: inositol 1»
↑ Yamamoto-Hino M, Sugiyama T, Hikichi K; et al. (1994). «Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors». Recept. Channels. 2 (1): 9–22. PMID 8081734 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)

Leitura de apoio

JardÃn I, LÃ³pez JJ, Salido GM, Rosado JA (2008). «Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets.». Cell. Signal. 20 (4): 737–47. PMID 18249094. doi:10.1016/j.cellsig.2007.12.010 soft hyphen character character in |autor= at position 6 (ajuda) !CS1 manut: Nomes múltiplos: lista de autores (link)
Wilker E, Mittleman MA, Litonjua AA; et al. (2009). «Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.». Environ. Health Perspect. 117 (6): 935–40. PMC 2702409. PMID 19590686. doi:10.1289/ehp.0800279 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Rosado JA, Sage SO (2001). «Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets.». Biochem. J. 356 (Pt 1): 191–8. PMC 1221827. PMID 11336651. doi:10.1042/0264-6021:3560191
van Es MA, Van Vught PW, Blauw HM; et al. (2007). «ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study.». Lancet neurology. 6 (10): 869–77. PMID 17827064. doi:10.1016/S1474-4422(07)70222-3 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Harzheim D, Movassagh M, Foo RS; et al. (2009). «Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.». Proc. Natl. Acad. Sci. U.S.A. 106 (27): 11406–11. PMC 2708695. PMID 19549843. doi:10.1073/pnas.0905485106 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Rosado JA, Sage SO (2000). «Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted.». Biochem. J. 350 Pt 3: 631–5. PMC 1221291. PMID 10970773
Uhl GR, Liu QR, Drgon T; et al. (2008). «Molecular genetics of successful smoking cessation: convergent genome-wide association study results.». Arch. Gen. Psychiatry. 65 (6): 683–93. PMC 2430596. PMID 18519826. doi:10.1001/archpsyc.65.6.683 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
ChiÃ² A, Schymick JC, Restagno G; et al. (2009). «A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.». Hum. Mol. Genet. 18 (8): 1524–32. PMC 2664150. PMID 19193627. doi:10.1093/hmg/ddp059 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Miyachi K, Iwai M, Asada K; et al. (2007). «Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with SjÃ¶gren's syndrome and other systemic rheumatic diseases.». Mod Rheumatol. 17 (2): 137–43. PMID 17437169. doi:10.1007/s10165-006-0555-6 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). «Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.». Genome Res. 16 (1): 55–65. PMC 1356129. PMID 16344560. doi:10.1101/gr.4039406 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Mery L, Magnino F, Schmidt K; et al. (2001). «Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.». FEBS Lett. 487 (3): 377–83. PMID 11163362. doi:10.1016/S0014-5793(00)02362-0 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Diaz F, Bourguignon LY (2000). «Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells.». Cell Calcium. 27 (6): 315–28. PMID 11013462. doi:10.1054/ceca.2000.0126
Mayne M, Holden CP, Nath A, Geiger JD (2000). «Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.». J. Immunol. 164 (12): 6538–42. PMID 10843712 !CS1 manut: Nomes múltiplos: lista de autores (link)
Tanimura A, Tojyo Y, Turner RJ (2000). «Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.». J. Biol. Chem. 275 (35): 27488–93. PMID 10874040. doi:10.1074/jbc.M004495200 !CS1 manut: Nomes múltiplos: lista de autores (link)
Jurkovicova D, Sedlakova B, Lacinova L; et al. (2008). «Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.». Ann. N. Y. Acad. Sci. 1148: 421–7. PMID 19120137. doi:10.1196/annals.1410.034 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI (2002). «Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling.». J. Biol. Chem. 277 (2): 1340–8. PMID 11694504. doi:10.1074/jbc.M106609200 !CS1 manut: Nomes múltiplos: lista de autores (link)
Suzuki Y, Yamashita R, Shirota M; et al. (2004). «Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.». Genome Res. 14 (9): 1711–8. PMC 515316. PMID 15342556. doi:10.1101/gr.2435604 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Tovey SC, Dedos SG, Taylor EJ; et al. (2008). «Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP.». J. Cell Biol. 183 (2): 297–311. PMC 2568025. PMID 18936250. doi:10.1083/jcb.200803172 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Johnson JM, Castle J, Garrett-Engele P; et al. (2003). «Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.». Science. 302 (5653): 2141–4. PMID 14684825. doi:10.1126/science.1090100 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)