TRIP12

Gene of the species Homo sapiens
TRIP12
Identifiers
AliasesTRIP12, TRIP-12, ULF, thyroid hormone receptor interactor 12
External IDsOMIM: 604506; MGI: 1309481; HomoloGene: 44226; GeneCards: TRIP12; OMA:TRIP12 - orthologs
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[1]
Chromosome 1 (mouse)
Genomic location for TRIP12
Genomic location for TRIP12
Band1|1 C5Start84,721,189 bp[1]
End84,840,516 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
    n/a
Top expressed in
  • spermatid

  • spermatocyte

  • seminiferous tubule

  • Gonadal ridge

  • primitive streak

  • medullary collecting duct

  • hair follicle

  • conjunctival fornix

  • primary oocyte

  • urothelium
BioGPS
More reference expression data
Gene ontology
Molecular function
  • thyroid hormone receptor binding
  • protein binding
  • ubiquitin-protein transferase activity
  • transferase activity
  • ubiquitin protein ligase activity
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
  • nuclear speck
  • cytoplasm
Biological process
  • negative regulation of double-strand break repair
  • negative regulation of histone H2A K63-linked ubiquitination
  • DNA repair
  • protein ubiquitination
  • embryo development
  • cellular response to DNA damage stimulus
  • protein polyubiquitination
  • ubiquitin-dependent protein catabolic process
  • regulation of embryonic development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9320

14897

Ensembl

ENSG00000153827

ENSMUSG00000026219

UniProt

Q14669

G5E870

RefSeq (mRNA)

NM_001284214
NM_001284215
NM_001284216
NM_004238

NM_133975

RefSeq (protein)
NP_001271143
NP_001271144
NP_001271145
NP_004229
NP_001335244

NP_001335245
NP_001335246
NP_001335247
NP_001335248
NP_001335249
NP_001335250
NP_001335251
NP_001335252
NP_001335253
NP_001335254
NP_001335255
NP_001335256
NP_001335257
NP_001335258
NP_001335259
NP_001335260
NP_001335261
NP_001335262
NP_001335263
NP_001335264
NP_001335265

NP_598736

Location (UCSC)n/aChr 1: 84.72 – 84.84 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Probable E3 ubiquitin-protein ligase TRIP12 is an enzyme that in humans is encoded by the TRIP12 gene.[4][5]


Interactions

TRIP12 has been shown to interact with APPBP1.[6]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026219 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
  5. ^ "Entrez Gene: TRIP12 thyroid hormone receptor interactor 12".
  6. ^ Park, Yoon; Yoon Sungjoo Kim; Yoon Jong-Bok (Sep 2008). "TRIP12 functions as an E3 ubiquitin ligase of APP-BP1". Biochem. Biophys. Res. Commun. 374 (2). United States: 294–8. doi:10.1016/j.bbrc.2008.07.019. PMID 18627766.

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.


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