SESTD1

Protein-coding gene in the species Homo sapiens
SESTD1
Identifiers
AliasesSESTD1, SOLO, SEC14 and spectrin domain containing 1
External IDsMGI: 1916262; HomoloGene: 45505; GeneCards: SESTD1; OMA:SESTD1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SESTD1
Genomic location for SESTD1
Band2q31.2Start179,101,678 bp[1]
End179,264,832 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SESTD1
Genomic location for SESTD1
Band2|2 C3Start77,010,684 bp[2]
End77,110,936 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • corpus callosum

  • lateral nuclear group of thalamus

  • gastric mucosa

  • inferior ganglion of vagus nerve

  • subthalamic nucleus

  • cartilage tissue

  • secondary oocyte

  • nasal epithelium

  • gonad
Top expressed in
  • otolith organ

  • utricle

  • trigeminal ganglion

  • hand

  • medial dorsal nucleus

  • Paneth cell

  • lobe of cerebellum

  • lateral geniculate nucleus

  • medial geniculate nucleus

  • spinal ganglia
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phosphatidic acid binding
  • phosphatidylinositol-4-phosphate binding
  • phosphatidylinositol-5-phosphate binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • 1-phosphatidylinositol binding
  • protein binding
  • phosphatidylserine binding
  • phosphatidylinositol-3-phosphate binding
  • phosphatidylinositol-3,5-bisphosphate binding
  • phosphatidylcholine binding
  • phosphatidylinositol-3,4-bisphosphate binding
Cellular component
  • calcium channel complex
  • intermediate filament cytoskeleton
Biological process
  • negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

91404

228071

Ensembl

ENSG00000187231

ENSMUSG00000042272

UniProt

Q86VW0

Q80UK0

RefSeq (mRNA)

NM_178123

NM_175465

RefSeq (protein)

NP_835224

NP_780674

Location (UCSC)Chr 2: 179.1 – 179.26 MbChr 2: 77.01 – 77.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SEC14 and spectrin domains 1, also known as SEC14 domain and spectrin repeat-containing protein 1 and Solo, is a protein that in humans is encoded by the SESTD1 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187231 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042272 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SEC14 and spectrin domains 1".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sato T, Mishina M (2003). "Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior". Genomics. 82 (2): 218–29. doi:10.1016/S0888-7543(03)00071-5. PMID 12837271.
  • Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Miehe S, Bieberstein A, Arnould I, et al. (2010). "The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5". J. Biol. Chem. 285 (16): 12426–34. doi:10.1074/jbc.M109.068304. PMC 2852980. PMID 20164195.
  • Trynka G, Zhernakova A, Romanos J, et al. (2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


  • v
  • t
  • e