SEPT8

Protein-coding gene in the species Homo sapiens
SEPTIN8
Identifiers
AliasesSEPTIN8, SEP2, septin 8, SEPT8
External IDsOMIM: 608418; MGI: 894310; HomoloGene: 57205; GeneCards: SEPTIN8; OMA:SEPTIN8 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SEPTIN8
Genomic location for SEPTIN8
Band5q31.1Start132,750,819 bp[1]
End132,807,241 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SEPTIN8
Genomic location for SEPTIN8
Band11 B1.3|11 31.96 cMStart53,410,084 bp[2]
End53,440,392 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • C1 segment

  • Brodmann area 23

  • endothelial cell

  • corpus callosum

  • inferior ganglion of vagus nerve

  • postcentral gyrus

  • entorhinal cortex

  • subthalamic nucleus

  • right frontal lobe
Top expressed in
  • facial motor nucleus

  • visual cortex

  • primary visual cortex

  • superior frontal gyrus

  • interventricular septum

  • cerebellar cortex

  • Region I of hippocampus proper

  • primary motor cortex

  • anterior horn of spinal cord

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • protein binding
  • GTPase activity
  • molecular adaptor activity
Cellular component
  • cytoplasm
  • cytoskeleton
  • septin ring
  • microtubule cytoskeleton
  • septin complex
  • septin filament array
  • presynapse
  • membrane
  • cell junction
  • axon
  • synaptic vesicle membrane
  • cytoplasmic vesicle
  • cell projection
  • synapse
Biological process
  • mitotic cytokinesis
  • septin ring assembly
  • cilium assembly
  • regulation of SNARE complex assembly
  • cytoskeleton-dependent cytokinesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23176

20362

Ensembl

ENSG00000164402

ENSMUSG00000018398

UniProt

Q92599

Q8CHH9

RefSeq (mRNA)
NM_001098811
NM_001098812
NM_001098813
NM_001300798
NM_001300799

NM_015146

NM_001252332
NM_001252333
NM_033144
NM_001347496
NM_001361968

NM_001361969

RefSeq (protein)
NP_001092281
NP_001092282
NP_001092283
NP_001287727
NP_001287728

NP_055961

NP_001239261
NP_001239262
NP_001334425
NP_149156
NP_001348897

NP_001348898

Location (UCSC)Chr 5: 132.75 – 132.81 MbChr 11: 53.41 – 53.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Septin-8 is a protein that in humans is encoded by the SEPT8 gene.[5][6][7]

Function

SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.[7]

Interactions

SEPT8 has been shown to interact with PFTK1[8] and SEPT5.[9][10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164402 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018398 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  6. ^ Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM (May 1997). "Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region". Genome Research. 7 (5): 495–512. doi:10.1101/gr.7.5.495. PMID 9149945.
  7. ^ a b "Entrez Gene: SEPT8 septin 8".
  8. ^ Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.
  9. ^ Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
  10. ^ Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. Bibcode:2002FEBSL.519..169B. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. S2CID 30822245.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Wenderfer SE, Slack JP, McCluskey TS, Monaco JJ (February 2000). "Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11". Genomics. 63 (3): 354–73. doi:10.1006/geno.1999.6100. PMID 10704283.
  • Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. Bibcode:2002FEBSL.519..169B. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. S2CID 30822245.
  • Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.
  • Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B (December 2002). "Mammalian septins nomenclature". Molecular Biology of the Cell. 13 (12): 4111–3. doi:10.1091/mbc.E02-07-0438. PMC 138619. PMID 12475938.
  • Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
  • Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B (May 2004). "The novel human platelet septin SEPT8 is an interaction partner of SEPT4". Thrombosis and Haemostasis. 91 (5): 959–66. doi:10.1160/TH03-09-0578. PMID 15116257. S2CID 22853459.
  • Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J (September 2004). "Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol". The Biochemical Journal. 382 (Pt 3): 783–91. doi:10.1042/BJ20040372. PMC 1133953. PMID 15214843.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Bläser S, Röseler S, Rempp H, Bartsch I, Bauer H, Lieber M, Lessmann E, Weingarten L, Busse A, Huber M, Zieger B (September 2006). "Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5". The Journal of Pathology. 210 (1): 103–10. doi:10.1002/path.2013. PMID 16767699. S2CID 45797279.
  • Xin X, Pache M, Zieger B, Bartsch I, Prünte C, Flammer J, Meyer P (November 2007). "Septin expression in proliferative retinal membranes". The Journal of Histochemistry and Cytochemistry. 55 (11): 1089–94. doi:10.1369/jhc.7A7188.2007. PMC 3957527. PMID 17625225.
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