ESX1

Protein-coding gene in humans
ESX1
Identifiers
AliasesESX1, ESX1L, ESXR1, ESX homeobox 1
External IDsOMIM: 300154; HomoloGene: 49152; GeneCards: ESX1; OMA:ESX1 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for ESX1
Genomic location for ESX1
BandXq22.2Start104,250,038 bp[1]
End104,254,933 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • right testis

  • left testis

  • gonad

  • epithelium of colon

  • placenta

  • endometrium

  • human musculoskeletal system

  • muscular system

  • skeletal striated muscle
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • sequence-specific DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • cytoplasm
  • nuclear speck
Biological process
  • negative regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80712

n/a

Ensembl

ENSG00000123576

n/a

UniProt

Q8N693

n/a

RefSeq (mRNA)

NM_153448

n/a

RefSeq (protein)

NP_703149

n/a

Location (UCSC)Chr X: 104.25 – 104.25 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Homeobox protein ESX1 is a protein that in humans is encoded by the ESX1 gene.[3][4][5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123576 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Fohn LE, Behringer RR (May 2001). "ESX1L, a novel X chromosome-linked human homeobox gene expressed in the placenta and testis". Genomics. 74 (1): 105–8. doi:10.1006/geno.2001.6532. PMID 11374906.
  4. ^ Loschiavo M, Nguyen QK, Duselis AR, Vrana PB (Feb 2007). "Mapping and identification of candidate loci responsible for Peromyscus hybrid overgrowth". Mamm Genome. 18 (1): 75–85. doi:10.1007/s00335-006-0083-x. PMC 1794137. PMID 17242862.
  5. ^ "Entrez Gene: ESX1 extraembryonic, spermatogenesis, homeobox 1 homolog (mouse)".

Further reading

  • Murthi P, Doherty VL, Said JM, et al. (2006). "Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction". Mol. Hum. Reprod. 12 (5): 335–40. doi:10.1093/molehr/gal037. PMID 16613891.
  • Figueiredo AL, Salles MG, Albano RM, Porto LC (2005). "Molecular and morphologic analyses of expression of ESX1L in different stages of human placental development". J. Cell. Mol. Med. 8 (4): 545–50. doi:10.1111/j.1582-4934.2004.tb00479.x. PMC 6740265. PMID 15601583.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ozawa H, Ashizawa S, Naito M, et al. (2004). "Paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradation". Oncogene. 23 (39): 6590–602. doi:10.1038/sj.onc.1207884. PMID 15235584.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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