CYP109 family

Family of cytochrome P450 enzymes

Cytochrome P450, family 109, also known as CYP109, is a cytochrome P450 monooxygenase family,^[1] many members are associated with fatty acid hydroxylation.^[2] The first gene identified in this family is the CYP109A1 and CYP109B1 from Bacillus subtilis.^[3] CYP109 is one of the only three P450 familis shared in bacteria and archaea, the other two are CYP147 and CYP197.^[1] Genes in this family are co-present on archaeal plasmids and chromosomes, implying the plasmid-mediated horizontal gene transfer of these genes from bacteria to archaea.^[1]

References

^ ^a ^b ^c Ngcobo, PE; Nkosi, BVZ; Chen, W; Nelson, DR; Syed, K (19 February 2023). "Evolution of Cytochrome P450 Enzymes and Their Redox Partners in Archaea". International Journal of Molecular Sciences. 24 (4): 4161. doi:10.3390/ijms24044161. PMC 9962201. PMID 36835573.
^ Khatri, Y; Hannemann, F; Girhard, M; Kappl, R; Même, A; Ringle, M; Janocha, S; Leize-Wagner, E; Urlacher, VB; Bernhardt, R (January 2013). "Novel family members of CYP109 from Sorangium cellulosum So ce56 exhibit characteristic biochemical and biophysical properties". Biotechnology and Applied Biochemistry. 60 (1): 18–29. doi:10.1002/bab.1087. PMID 23586989.
^ Girhard M, Klaus T, Khatri Y, Bernhardt R, Urlacher VB (June 2010). "Characterization of the versatile monooxygenase CYP109B1 from Bacillus subtilis". Applied Microbiology and Biotechnology. 87 (2): 595–607. doi:10.1007/s00253-010-2472-z. PMID 20186410. S2CID 26265331.