CTDNEP1

CTDNEP1
Identifiers
Aliases	CTDNEP1, DULLARD, HSA011916, NET56, CTD nuclear envelope phosphatase 1
External IDs	OMIM: 610684; MGI: 1914431; HomoloGene: 9100; GeneCards: CTDNEP1; OMA:CTDNEP1 - orthologs
Gene location (Mouse) Chr. Chromosome 11 (mouse)[1] Band 11|11 B3 Start 69,871,982 bp[1] End 69,881,427 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue ganglionic eminence stromal cell of endometrium skin of abdomen canal of the cervix spleen smooth muscle tissue lymph node uterine tube Top expressed in muscle of thigh lip dentate gyrus of hippocampal formation granule cell skeletal muscle tissue tail of embryo ventricular zone ankle genital tubercle superior frontal gyrus upper arm More reference expression data BioGPS n/a
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein serine/threonine phosphatase activity protein binding hydrolase activity Cellular component cytoplasm integral component of membrane nuclear membrane nuclear envelope endoplasmic reticulum membrane membrane Nem1-Spo7 phosphatase complex endoplasmic reticulum nucleus lipid droplet Biological process positive regulation of triglyceride biosynthetic process nuclear envelope organization positive regulation of canonical Wnt signaling pathway protein dephosphorylation gamete generation mitotic nuclear membrane disassembly protein localization to nucleus mesoderm development dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23399 67181 Ensembl n/a ENSMUSG00000018559 UniProt O95476 Q3TP92 RefSeq (mRNA) NM_015343 NM_001143775 NM_026017 RefSeq (protein) NP_001137247 NP_056158 NP_080293 Location (UCSC) n/a Chr 11: 69.87 – 69.88 Mb PubMed search [2] [3]
Wikidata
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In cell biology, CTDNEP1 (CTD nuclear envelope phosphate 1) is a protein coding gene involved in neural development. It is a member of DXDX(T/V) phosphatase family and is a potential regulator of neural tube development in Xenopus. The gene promotes neural development by inhibiting Bone Morphogenetic Proteins (BMPs). The encoded protein is relatively small and only contains 244 amino acids.

Description

CTDnep1, which stands for CTD nuclear envelope phosphatase 1. It is a protein coding gene, which include phosphatase activity and protein serine/threonine phosphatase activity. CTDnep1 encodes a protein serine/threonine phosphatase and dephosphoroylates LPIN1 and LPIN2. LPIN1 and LPIN2 catalyze the reaction of the conversion of phosphatidic acid to diacylglycerol. The reaction can affect and change the lipid concentration of the endoplasmic reticulum and the nucleus.

Dullard and BNP signaling

Neural development happens in the dorsal ectoderm. In the genus Xenopus, over expression of CTDNEP1 undergoes apoptosis in early development. CTDNEP1 helps promote Ubiquitin by proteosomal degradation. CTDNEP1 mRNA is derived from maternal genes and is localized within the animal neural hemisphere. Functioning negatively for the regulation of Bone Morphogenetic Proteins (BMPs), CTDNEP1 conserves the C-terminal region of NLI-IF, in which is fairly dominant in cellular functions. CTDNEP1 is essential for inhibiting BMP receptor activation during Xenopus neuralization.

Human Dullard

Human CTDNEP1 has shown that the protein has two membrane spanning regions. One end is the N-terminal end, which helps localize the protein to the nuclear envelope. CTDNEP1 dephosphorylates the mammalian phospatidic acid phosphatase, lipin. CTDNEP1 participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and that this cascade is conserved from yeast to mammals. There is belief that CTDNEP1 may have other targets that is not only associated with the nuclear envelope. In recent studies, CTDNEP1 interacts with BMP type 1 to inhibit dependent phosphorylation. This can conclude that it is a potential source for regulating the level of BMP signaling and can affect germ cell specification.

CTD nuclear envelope phosphatase 1 is a protein in humans that is encoded by the CTDNEP1 gene. ^[4]

References